Journal article
Alzbeta Filipova, Matus Tomko, Katarina Ondacova, Lucia Dubiel-Hoppanova, Nikola Chmúrčiaková, Leos Cmarko, Robin N. Stringer, Norbert Weiss, Ľ. Lacinová
Molecular Brain, 2025
Molecular Brain, 2025
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Filipova, A., Tomko, M., Ondacova, K., Dubiel-Hoppanova, L., Chmúrčiaková, N., Cmarko, L., … Lacinová, Ľ. (2025). Homocysteine enhances the excitability of cultured hippocampal neurons without altering the gene expression of voltage-gated ion channels. Molecular Brain.
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Filipova, Alzbeta, Matus Tomko, Katarina Ondacova, Lucia Dubiel-Hoppanova, Nikola Chmúrčiaková, Leos Cmarko, Robin N. Stringer, Norbert Weiss, and Ľ. Lacinová. “Homocysteine Enhances the Excitability of Cultured Hippocampal Neurons without Altering the Gene Expression of Voltage-Gated Ion Channels.” Molecular Brain (2025).
MLA
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Filipova, Alzbeta, et al. “Homocysteine Enhances the Excitability of Cultured Hippocampal Neurons without Altering the Gene Expression of Voltage-Gated Ion Channels.” Molecular Brain, 2025.
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@article{alzbeta2025a,
title = {Homocysteine enhances the excitability of cultured hippocampal neurons without altering the gene expression of voltage-gated ion channels},
year = {2025},
journal = {Molecular Brain},
author = {Filipova, Alzbeta and Tomko, Matus and Ondacova, Katarina and Dubiel-Hoppanova, Lucia and Chmúrčiaková, Nikola and Cmarko, Leos and Stringer, Robin N. and Weiss, Norbert and Lacinová, Ľ.}
}
Abstract
Elevated plasma homocysteine (Hcy) levels lead to hyperhomocysteinemia, a condition associated with various neurological disorders affecting multiple brain regions, including the hippocampus. In this study, we investigated the effects of exposing cultured rat hippocampal neurons to Hcy concentrations corresponding to mild, moderate, and severe hyperhomocysteinemia. A short 24-hour exposure had minimal effects, whereas prolonged exposure up to 14 days moderately enhanced hippocampal excitability without altering the gene expression of voltage-dependent calcium, sodium, or potassium channels or intracellular calcium levels. These findings suggest that Hcy-induced changes in neuronal excitability may contribute to neuropathologies associated with hyperhomocysteinemia.
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