Unraveling the regulatory landscape of neuronal T-type calcium channel variants in human disease

This project explores how T-type calcium channel variants linked to human disorders are influenced by temperature, splicing, cellular context, and regulatory proteins, aiming to clarify their roles in disease and guide development of targeted therapies

Cardiac dysfunction as a central contributor to sudden unexpected death in epilepsy in Dravet Syndrome: mechanistic insights from cardiomyocytes derived from patient-induced pluripotent stem cells

Dravet syndrome, caused by SCN1A mutations, carries high SUDEP risk. This project studies patient-derived iPSC cardiomyocytes to uncover mutation-specific arrhythmias and link cardiac dysfunction to SUDEP, guiding new therapies

Development of new non-opioid calcium channel antagonists for pain management

Chronic pain affects ≥10% of people and is poorly treated by opioids. We aim to develop new painkillers targeting calcium channels using novel nitrogen-rich molecules as potential non-opioid therapeutics