A major focus of our laboratory is the mechanistic dissection of calcium channelopathies. We study disease-associated mutations at the functional level, linking molecular defects in channel gating and regulation to altered cellular phenotypes and, ultimately, to clinical manifestations. By combining electrophysiology, molecular and cellular biology, and targeted genetic approaches, we aim to bridge the gap between genotype and pathophysiology. 

Beyond channelopathies, we are interested in the broader physiological implications of calcium channel activity. We investigate how these channels are modulated by signaling pathways, interacting proteins, and cellular context, and how such regulation shapes neuronal and non-neuronal function. By integrating biophysical analysis with cellular and systems-level approaches, we aim to understand how finely tuned calcium influx orchestrates complex biological processes under physiological conditions.

Finally, we explore the pharmacology of calcium channels. Understanding how small molecules and modulators influence channel behavior not only provides mechanistic insight but also informs therapeutic strategies for disorders linked to channel dysfunction. We combine functional assays with structure–function analysis to define mechanisms of action and to identify compounds with improved selectivity and translational potential.